Relationship Between Metabolic and Histological Responses in People With Metabolic Dysfunction- Associated Steatohepatitis With and Without Type 2 Diabetes: Participant-Level Exploratory Analysis of the SYNERGY-NASH Trial With Tirzepatide.

When adjusting for percent change of weight, the correlation between change in Adipo-IR and MASH resolution remained statistically significant ( r = −0.19; P = 0.0298); changes in HbA 1c ( r = −0.16; P = 0.0539) and adiponectin ( r = 0.13; P = 0.1196) had strong trends but did not reach statistical significance, and the correlation with triglycerides was not significant ( P = 0.4979).

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