Impact of treatment history on drug resistance of metastatic colorectal cancer organoids.

iScience · 2025 · PMC12636388 · PMID 41280668

Europe PMC DOI

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0.0950

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0.0950

boldest claim

The sentences

showed a trendp = 0.095so close (0.05 < p ≤ 0.1)

When comparing PDOs with and without these signatures, those with SBS17a showed a trend toward 5-FU resistance ( p = 0.095) and were significantly more resistant to SN-38 (median GR AUC 0.74 vs. 0.53, p = 0.04, Figure 3 D).

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