Placental Angiogenic Imbalance and Its Association With Adverse Outcomes in Congenital Heart Disease Pregnancies.

Additionally, patients with low PlGF levels showed a trend toward increased adverse events compared to CHD women with non-reduced PlGF (66.7% vs 23.1%; P = 0.060; Figure 3B ), and those with a high sFlt-1/PlGF ratio also demonstrated a similar trend (62.5% vs 20.8%; P = 0.072; Figure 3C ).

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Specifically, among women with CHD, those with elevated sFlt-1 had a significantly higher incidence of adverse outcomes, whereas those with low PlGF or a high sFlt-1/PlGF ratio showed only a nonsignificant trend toward increased risk.

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