Conserved CD8 T cell vaccines without B cell epitopes drive robust protection against SARS-CoV-2 that is enhanced by intranasal boost.

Sci Adv · 2025 · PMC12637294 · PMID 41270167

Europe PMC DOI

hedged sentence

0.2200

closest p · 4.4× alpha

0.2200

boldest claim

The sentences

showed a trendP = 0.22not close (p > 0.1)

While S259 showed a trend toward reduction in viral load, the results were not statistically significant (adjusted P = 0.22).

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