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Vitamin D3 Improves Hypothalamic-Pituitary-Adrenal Axis Function, Immunological Responses, and Gut Dysbiosis in Sleep Desynchrony.

Brain Behav · 2025 · PMC12638446 · PMID 41273001

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Analysis of clock‐related gene expression revealed that the CSD group exhibited higher expression levels of Bmal‐1 and clock compared with the NS group; however, the increase in Bmal‐1 expression did not reach statistical significance (Figure 3D,E ), suggesting that sleep desynchrony upregulated these genes.

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