Prognostic value of blood-based biomarkers in multiple sclerosis patients in the absence of clinical relapses or new MRI lesions.

In contrast, the change in lesion volume (ΔLV) between baseline and follow-up was highly significant (mean: 1.08 ± 1.45 vs −0.65 ± 1.06 ml; p < 0.0001) and remained robust after FDR correction ( q = 0.0009).

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Consistent with the results from the blood-based biomarkers, patients with increasing LV exhibited lower GM volume both at baseline (mean GMF: 0.43 ± 0.04 vs 0.44 ± 0.03; p = 0.0209), which showed a trend after FDR correction ( q = 0.0627), and at follow-up (mean GMF: 0.42 ± 0.04 vs 0.44 ± 0.03; p = 0.0109), which remained significant after correction ( q = 0.0490; Table 2 ).

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