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A Comparison of the Risk of Viral Load Blips in Human Immunodeficiency Virus Patients on Two-Drug Versus Three-Drug Antiretroviral Regimens.

Infect Dis Rep · 2025 · PMC12641778 · PMID 41283345

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For blips defined as HIV-RNA ≥ 50 copies/mL, patients receiving three-drug regimens had an odds ratio (OR) of 2.64 (95% confidence interval [CI]: 0.91–7.70; p = 0.075) compared with those receiving two-drug regimens, but this difference did not reach statistical significance ( Table 4 ).

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