Comparative efficacy of multiple drugs for non-alcoholic fatty liver disease: a Bayesian network meta-analysis.

As shown in Figure S4, in terms of improvement in lipid profiles, GLP-1RA, SGLT-2I, TZD, and vitamin E all showed a trend toward reduction in TG compared with placebo, with GLP-1RA showing the highest probability (SUCRA: 87.50%); except GLP-1RA, the other three drugs did not show a trend toward reduction in TC; and none of the four drugs showed a trend toward a beneficial effect in improving LDL-C compared with placebo.

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Regarding lipid improvement, all four interventions showed a possible trend toward lowering TG, with GLP-1RA demonstrating a benefit over placebo in sensitivity analyses (MD: − 0.39, 95% CI − 0.77 to − 0.02).

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