The cell cycle regulator PLK1 promotes murine melanoma progression by regulating the transcription factor BACH1.

PLoS Biol · 2025 · PMC12643297 · PMID 41284701

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did not reach statistical significanceno p-value reported

In addition, the frequency of lymph nodes carrying macro-metastasis increased in Braf CA/+ / Pten loxp/loxp / Plk1 mice compared to Braf CA/+ / Pten loxp/loxp mice ( Figs 1K and S1E ), while the incidence of distant metastasis was raised but did not reach statistical significance ( Fig 1L ).

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