Barely Significant
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Matrix metalloproteinases are hallmark early biomarkers and therapeutic targets in FSHD.

JCI Insight · 2025 · PMC12643495 · PMID 40966415

Europe PMCDOI
1
hedged sentence
0.0800
closest p · 1.6× alpha
0.0800
boldest claim

The sentences

did not reach statistical significanceP = 0.08so close (0.05 < p ≤ 0.1)
Although the difference did not reach statistical significance ( P = 0.08) and MMP9 was not identified as a reliable serum biomarker in that study, our data demonstrated robust MMP9 upregulation in both patient biopsies and in response to DUX4 expression in muscle fibers.

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