Peanut allergy oral immunotherapy drives single-cell multi-omic changes in peanut-reactive T cells associated with sustained unresponsiveness.

The pr T H 1 CTL feature gene module score showed a consistent trend of higher values in SU compared to DS participants across all time points; it most closely approached significance at week 117 (Fig. 5b , right; P = 0.053).

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4k , P = 0.054), while the frequency of expanded pr T H 1 CTL-like cells within the pr T H 1 CTL cluster or among pr T eff memory cells showed a nonsignificant trend toward higher values in SU compared to DS participants at week 117 (Fig. 4j , P = 0.37; Fig. 4k , P = 0.17).

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2a ; q = 0.02); the frequency of T H 2conv-like, T H 22 and T H 17-like, and T eff -act2 cells each showed a decreasing trend (Fig. 2a ; q = 0.09, q = 0.09 and q = 0.1, respectively).

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