The probiotic <i>Limosilactobacillus fermentum</i> CECT5716 enhances the antihypertensive response to hydrochlorothiazide in spontaneously hypertensive rats.

Moreover, the administration of LC40, either alone or in combination with HCTZ50, showed a tendency toward an increased relative abundance of propionate-producing bacteria ( Figure 3 E), predominantly Akkermansia (Figure S4)), in line with previous observations in obese murine models, 32 although this effect did not reach statistical significance.

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