Androgen deprivation-mediated activation of AKT is enhanced in prostate cancer with TMPRSS2:ERG fusion.

J Clin Invest · 2025 · PMC12646650 · PMID 41321318

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did not reach statistical significanceno p-value reported

A subsequent analysis of the IPATential150 trial (published while this manuscript was under revision) found that while there was an increase in median overall survival in men with PTEN -deficient tumors (from 29.8 months in the placebo control group to 36.8 months in the ipatasertib arm), this did not reach statistical significance ( 46 ).

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