Kidney-specific claudin-2 deficiency leads to medullary nephrocalcinosis in mice.

Bone mineral density at the lumbar spine and femur, or summed over the whole body ( Figure 4D ), tended on average to be lower in the KO mice at all ages, but the differences did not reach statistical significance.

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We observed a nonsignificant trend toward greater natriuresis in response to furosemide in females compared with males and significantly greater calciuresis ( Figure 6B ).

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