The significance of perioperative glucocorticoids in the prevention of seroma formation after mastectomies: a systematic review and meta-analysis.

The subgroup analysis indicated a nonsignificant trend toward lower wound infection rates with postoperative GCs (RR = 1.12, 95% CI 0.02; 61.20, p = 0.785) compared to preoperative use (RR = 1.39, 95% CI 0.69; 2.79, p = 0.235), but these differences were not statistically meaningful.

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The rate of wound infection showed a higher trend in the intervention groups (RR = 1.26, CI 0.82; 1.92, p = 0.224), although the results did not reach statistical significance, Conclusions Our results suggest that perioperative glucocorticoid administration may reduce seroma formation in patients undergoing mastectomy.

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