A unique extracellular matrix at EC-DG synapses The proteome of EC-DG synapses presented several DE proteoglycans, including Bcan, Ncan, Agrn and Hspg2 (Vcan and Cspg5 also presented highest expression in EC-DG, but did not reach statistical significance, Fig. 3 ).
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Synaptic proteome diversity is shaped by the levels of glutamate receptors and their regulatory proteins.
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