Multi-omic analysis reveals lipid dysregulation associated with mitochondrial dysfunction in parkinson's disease brain.

Nat Commun · 2025 · PMC12647800 · PMID 41290621

Europe PMC DOI

hedged sentences

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closest p · 0.0× alpha

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boldest claim

The sentences

highly significantp = 3.1 E -10actually significant

This model was found to be highly significant (ANOVA CV p = 3.1 E -10 ) and no regional influence could be discerned.

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nominally significantno p-value reported

The results showed that three sphingomyelins significantly correlated with the abundances of several proteins, positively with 14 proteins and negatively with 29 proteins, while in total, 25 of these proteins were nominally significant between PD and control in the proteomic data alone.

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