showed a trendp = 0.29
Gene expression of markers for microglia, Ionized calcium-binding adapter molecule 1 ( Iba1) and cluster of differentiation 68 ( Cd68 ), showed a trend of downregulating in SP8-Ap mice compared to SP8-C mice ( Iba1 , p = 0.29, d = 0.22; Cd68 , p = 0.18, d = 0.31).