A genome-wide association study about presbycusis and brain cortical structure: Neuroimaging traits from a Mendelian randomization study.

Thus, P<2.26×10-4 (2.26×10-4 = 0.05/ (138+83); The number 138 indicates the total count of cases with or without global weighted SA/TH of cortical structure, while 83 represents the total volume of cortical structure) was regarded as significant, whereas P < 0.05 was considered nominally significant and suggestive. 2.4 Ethics As a meta-analysis of previously published GWAS results involving no new human subjects research, this study did not require separate ethical clearance. 3 Results Ultimately, 15 SNPs associated with presbycusis were retained for MR analysis.

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