Serum PTH ≥ 40 pg/mL as a Marker of Bone Fragility and Vitamin D Deficiency in Periodontitis Patients: Biochemical, Densitometric and Genetic Evidence.

Biomolecules · 2025 · PMC12649829 · PMID 41301518

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a positive trendno p-value reported

As shown in Figure 5 , a positive trend was observed between the genetic polymorphism score and PTH levels, suggesting a potential interaction whereby a higher burden of polymorphic alleles may predispose individuals to elevated PTH levels.

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did not reach statistical significanceno p-value reported

While the trend observed for VDR polymorphisms did not reach statistical significance, the overall direction of the data supports the hypothesis of a gene–environment interaction affecting skeletal outcomes [ 35 , 36 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.