Artificial Intelligence-Guided Molecular Determinants of PI3K Pathway Alterations in Early-Onset Colorectal Cancer Among High-Risk Groups Receiving FOLFOX.

Biomedicines · 2025 · PMC12650178 · PMID 41301724

Europe PMC DOI

hedged sentence

0.0530

closest p · 1.1× alpha

0.0530

boldest claim

The sentences

approached significancep = 0.053so close (0.05 < p ≤ 0.1)

In LOCRC, MTOR mutations were significantly reduced in the treated group (4.5%) versus untreated (7.8%, p = 0.007), and AKT2 mutations approached significance (0.7% vs. 1.8%, p = 0.053).

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