Folate Attenuates Ulcerative Colitis via PI3K/AKT/NF-κB/MLCK Axis Inhibition to Restore Intestinal Barrier Integrity.

Inverse variance-weighted (IVW) analysis revealed no significant causal associations between most vitamins and CD risk except for genetically proxied vitamin B6, which demonstrated a nominally significant inverse causal association with reduced disease risk (OR = 0.453, 95% CI = 0.207–0.994; p = 0.048) ( Figure 1 A).

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Although both vitamins B6 and B9 currently suffer from limited numbers of associated SNPs, the borderline significance and wide confidence interval particularly compromise the statistical robustness of the vitamin B6 association.

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