Downregulation of Enteroendocrine Genes Predicts Survival in Colon Cancer: A Bioinformatics-Based Analysis.

Int J Mol Sci · 2025 · PMC12652218 · PMID 41303610

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While the average causal mediation effect (ACME) index showed a trend of a negative indirect effect via SOX9 and LYZ, it was not statistically significant (ACME < 0.05 ), suggesting that the Wnt signaling modulation of EEC markers occurs predominantly through a direct mechanism ( Table 2 ).

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