Fibroblast Activation Protein Alpha (FAP) Expression Is Associated with Disease Recurrence and Poor Response to Tyrosine Kinase Inhibitors in Advanced Clear Cell Renal Cell Carcinoma.

FAP Expression Is Higher in Tumors with Advanced Stage and Metastatic Spread The proportion of FAP-positive (FAP+) tumors was higher among cases with locoregional lymph node metastases (73%) compared with those without nodal involvement (53%), although this difference did not reach statistical significance ( p = 0.16; Figure 2 d).

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FAP Expression Does Not Significantly Vary According to IMDC Risk Classification or ECOG Performance Status When stratified by IMDC risk classification, a decreasing trend in FAP expression was observed in tumors from patients with favorable prognosis compared to those with intermediate or poor prognosis, although the difference was not statistically significant ( Figure 2 g).

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