Juvenile and Osteoarthritic Human Chondrocytes Under Cyclic Tensile Strain: Transcriptional, Metabolic and Kinase Responses.

In both chondrocyte types, the application of cyclic tensile strain resulted in a highly significant reduction in NAD + /NADH levels more pronounced in pCH-OA and with a significant difference observed between the two cell lines ( Figure 5 b).

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In our cell systems, mechanical stimulation with the SM/SA profile led to a significant decrease in p-AKT and p-ERK, while p-p38 showed a trend toward an increase.

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