Mitochondrial DNA Deletions and Plasma GDF-15 Protein Levels Are Linked to Hormonal Dysregulation and Multi-Organ Involvement in Female Reproductive Endocrine Disorders.

Although mean AMH levels tended to be lower in patients with elevated GDF-15, this difference did not reach statistical significance ( Figure 4 A).

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A positive trend in deletion-positive patients could indicate a compensatory mechanism, whereas vitamin D may be insufficient to counteract GDF-15 upregulation in metabolically burdened states.

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