Muscle Unloading During Exercise: Comparative Effects of Conventional Oxygen, NIV, and High-Flow Therapy on Neural Drive in Severe COPD.

Among the three experimental conditions, NIV was associated with the greatest reduction in respiratory muscle effort during exercise, reflected in highly significant decreases in both peak and area NRD values for the EMGpara compared with COT and HFT: EMGpara NRD peaks: ▪ Within-subject: F (6,14) = 8.970, p < 0.001, η 2 = 0.79, β −1 = 0.99. ▪ Between-subject: F (2,18) = 9.116, p < 0.01, η 2 = 0.50, β −1 = 0.94.

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For the patients who did not stop, the differences did not reach statistical significance.

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