Plasma Rich in Growth Factors (PRGF) Versus Saline Intraosseous Infiltrations Combined with Intra-Articular PRGF in Severe Knee Osteoarthritis: A Prospective Double-Blind Multicentric Randomized Controlled Trial with 1-Year Follow-Up.

J Clin Med · 2025 · PMC12653810 · PMID 41303112

Europe PMC DOI

hedged sentences

0.0010

closest p · 0.0× alpha

0.0500

boldest claim

The sentences

highly significantp < 0.001actually significant

For the intraosseous PRGF group, the improvements in Symptoms, Pain, Activities of Daily Living, Sports/recreation, and Quality of Life were highly significant ( p < 0.001) at all time-points compared to their baseline values.

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did not reach statistical significancep = 0.050actually significant

For the KOOS Activities of Daily Living domain, the intraosseous PRGF group also demonstrated significantly better results at 6 months ( p = 0.007) and 12 months ( p = 0.002), though the difference at 3 months did not reach statistical significance ( p = 0.050). 3.3.

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