Physiologically Based Pharmacokinetic Modeling of Clobazam and Stiripentol Co-Therapy in Dravet Syndrome.

J Pers Med · 2025 · PMC12653854 · PMID 41295251

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closest p

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a clear trendno p-value reported

Development and Validation of the PBPK Model for STP in Healthy Adults The predicted CL po for STP ranged from 8 to 70 L/h, showing a clear trend of reduced clearance at higher doses and following chronic administration.

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