Synchronous Versus Metachronous Multiple Malignant Tumors Involving the Digestive Tract: Predictors of Survival from a Single-Center Retrospective Study.

Medicina (Kaunas) · 2025 · PMC12654143 · PMID 41303799

Europe PMC DOI

hedged sentences

0.0530

closest p · 1.1× alpha

0.0530

boldest claim

The sentences

at the margin of statistical significancep = 0.053so close (0.05 < p ≤ 0.1)

The Kaplan–Meier curves and RMST comparison suggest substantially worse survival for synchronous presentations, with the effect at the margin of statistical significance ( p = 0.053 by log-rank).

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marginally non-significantno p-value reported

Similar but marginally non-significant effects were observed for nodal stage of the secondary tumor.

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did not reach statistical significanceno p-value reported

The adjusted hazard associated with synchronous presentation was attenuated (adjusted HR 2.22, 95% CI 0.84–5.86, p = 0.10) and did not reach statistical significance in the final, parsimonious model ( Table 4 ). 4.

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