Design, Synthesis, and Biological Evaluation of 5',7-Disubstituted 7-Deaza-adenosine Analogues as Irreversible Pan-FGFR Inhibitors.

Pharmaceuticals (Basel) · 2025 · PMC12655421 · PMID 41304987

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a clear trendno p-value reported

Among fused-ring analogs, a clear trend was observed in activity: benzofuran-2-yl ( 6d ) < indole-2-yl ( 6f ) < benzothiophen-2-yl ( 6e ), with 6e showing the most pronounced effect, particularly for FGFR4.

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