Barely Significant
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A Multiplex Serological Assay to Evaluate the Antibody Responses to a Set of <i>Plasmodium falciparum</i> Antigens and Their Protective Role Against Malaria in Children Aged 1.5 to 12 Years Living in a Highly Seasonal Malaria Transmission Area of Burkina Faso.

Vaccines (Basel) · 2025 · PMC12656952 · PMID 41295464

Europe PMCDOI
2
hedged sentences
0.0600
closest p · 1.2× alpha
0.0600
boldest claim

The sentences

marginally significantp = 0.06so close (0.05 < p ≤ 0.1)
Anti-AMA1 antibodies showed a marginally significant association with increased malaria risk: for the secondary case definition, the adjusted IRR was 1.28 (95% CI: 0.97–1.71; p = 0.06), with a similar trend for the primary case definition (IRR = 1.36; p = 0.06).

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did not reach statistical significanceno p-value reported
Some less well-studied antibodies, such as Etramp4 Ag2 (IRR = 0.53; p = 0.008) and HSP40 Ag1 (IRR = 0.49; p = 0.07), indicated a potential protective trend but did not reach statistical significance. 3.4.

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