Differential regulation of 5-lipoxygenase and leukotriene-C4-synthase expression by IFNγ, IL-4 and IL-13 in human monocytes and macrophages from patients with atopic dermatitis.

In our previous publication [ 16 ] using macrophages generated according to the similar protocol, intracellular staining revealed a significant upregulation of the differentiation marker CD68, while extracellular staining showed a trend toward increased expression of the scavenger receptor CD163 (indicative of M2 polarization) in M-CSF—differentiated macrophages compared to monocytes.

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