Fundamental sex differences in cocaine-induced plasticity of D1R- and D2R-MSNs in the mouse nucleus accumbens core.

Biol Sex Differ · 2025 · PMC12659347 · PMID 41299747

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0.0547

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a strong trendp = 0.0547so close (0.05 < p ≤ 0.1)

Following cocaine exposure, D1R-MSNs were significantly different from their untreated counterparts at select current injections (2-way repeated measures ANOVA, F 8,224 = 3.635, p = 0.0005), and there was a strong trend towards a main effect (2-way repeated measures ANOVA, F 1,28 = 4.021, p = 0.0547); significant differences were observed at 120–180 pA injections (Fig. 4 C, E).

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