GDNF signaling modulation by Akkermansia muciniphila ameliorates constipation-depression comorbidity in Parkinson's disease.

NPJ Parkinsons Dis · 2025 · PMC12663421 · PMID 41315295

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However, after GDNF intervention, the increased ubiquitination modification of NEDD4 disappeared, and TRAF6 overexpression showed a trend consistent with the RS09 group (Fig. 3O and P ).

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