IL-27Ra promotes the progression of neonatal necrotizing enterocolitis.

Sci Rep · 2025 · PMC12663434 · PMID 41315384

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The loss of IL-27Ra also blunted the NEC-induced inflammatory response: NEC-IL-27Ra -/- mice showed a trend toward reduced plasma IL-6 levels (Fig. 4 D), accompanied by significantly decreased IL-6 mRNA expression in intestinal tissue (Fig. 4 E).

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