Breast cancer cell coculture induces normal lung fibroblast transition to CAFs, promoting tumor cell dormancy and therapy resistance.

In contrast, lung metastases grew slowest in mice treated with SAR405, with a strong trend toward reduced endpoint tumor burden in mice treated with SAR405 alone as compared to MBC-613, and the addition of SAR405 to MCB-613 restored efficacy to near levels observed for single-agent SAR405 ( Fig. 6 A and B ).

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