We then focused on the different steps of myelin internalization by microglia, observing that TNFR2 deletion induced a trend toward a decrease in the percentage of “touching” microglia and a significant decrease in the fraction of “hungry” microglia, whereas “foamy” microglia showed a trend toward increase, albeit not significant ( Fig. 3 D–F).
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TNFR2 signaling shapes the sex-specific remyelinating properties of microglia after experimental stroke.
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