Mechano-Ino-Chronotropic Unloading in Cardiogenic Shock Due to Acute Myocardial Infarction-Hemodynamic Insights From Simulation Modeling.

They showed that ivabradine is safe and associated with favorable changes in systemic blood pressure, NT-proBNP, and LV ejection fraction, as well as with less mortality than the standard of care, although the latter finding did not reach statistical significance in this small trial of 58 individuals. 23 Nevertheless, this finding has stimulated broader use of ivabradine in individuals with decompensated heart failure who have heightened adrenergic tone driving deleterious degrees of tachycardia. 24 , 25 , 26 Additionally, our study shows further benefit to MIC-U, compared with mechanochronotropic unloading, without adverse effects on hemodynamics when adequate mechanical unloading is used.

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