Barely Significant
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Optimising GLP-1RA Efficacy: A Meta-Analysis of Baseline Age and HbA1c as Predictors of MACE Reduction in T2DM.

Diabetes Metab Syndr Obes · 2025 · PMC12665223 · PMID 41328392

Europe PMCDOI
1
hedged sentence
0.0034
closest p · 0.1× alpha
0.0034
boldest claim

The sentences

nearly significantp = 0.0034actually significant
The initial consideration of the duration of T2DM, despite its nearly significant univariate effect (p = 0.0034), highlights the necessity for multicollinearity checks, a step often missed in earlier meta-analyses. 21 , 22 Strengths and Limitations Strengths of this study include the comprehensive analysis of 11 CVOTs with 83,536 participants, a PRISMA-guided approach, and the use of random-effects models with meta-regression to explore moderators.

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