Maxing Shigan Decoction Alleviates Lung Heat Syndrome by Inhibiting α4β7-Mediated γδT17 Cell Migration Across the Gut-Lung-Nasal Axis.

The blockade of α4β7 significantly reduced γδT17 cell proportions in nasal mucosa and demonstrated a decreasing trend in intestinal tissue compared to PBS-treated LHS controls.

also in 47,180 other papers

While pulmonary γδT17 cell infiltration showed moderate reduction, this did not reach statistical significance ( Figure 9 ). α4β7 blockade markedly suppressed IL-17A production in the nasal compartment and showed a non-significant decreasing trend in the lung tissue.

also in 111,027 other papers