<i>Jchain</i>-diphtheria toxin receptor mice allow for depletion of antibody-secreting cells and analysis of differentiation kinetics.

At day 3, bone marrow ASCs appeared to still be reduced in DT-treated animals although this did not reach statistical significance ( Figure 7 F).

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Regardless, ASC depletion was still highly significant and clearly surpassed in magnitude what was previously achieved with antibody-mediated targeting of ASCs. 12 Critically, we observed potent depletion of all ASC isotypes examined in the spleen, bone marrow and thymus which included those expressing IgM, IgG and IgA Abs ( Figures 6 and S6 ).

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