Genetic signatures of responsiveness in idiopathic normal pressure Hydrocephalus: Insights from whole-exome and LASSO-based analysis.

Brain Spine · 2025 · PMC12666844 · PMID 41333149

Europe PMC DOI

hedged sentence

0.0560

closest p · 1.1× alpha

0.0560

boldest claim

The sentences

approaching significancep = 0.056so close (0.05 < p ≤ 0.1)

FANCD2 showed the strongest trend, with variants more frequent among non-responders and a p-value approaching significance (p = 0.056), suggesting a potential link between DDR-related defects and diminished clinical improvement.

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