Cerebral phosphorus metabolite as imaging biomarkers in Alzheimer's disease: a <sup>31</sup>P magnetic resonance spectroscopy study.

Meanwhile, the phosphomonoesters to phosphodiesters (PME/PDE) ratio in both the hippocampus and prefrontal gray matter exhibited a progressive increase along the HC–aMCI–AD disease continuum(all p < 0.001), although the difference between the aMCI and HC groups did not reach statistical significance in the frontal gray matter.

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