Prognostic impact of GNRI-IPI score in octogenarians with diffuse large B-Cell lymphoma treated with R-CHOP.

Ann Hematol · 2025 · PMC12672595 · PMID 41085685

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closest p · 1.1× alpha

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borderline significancep = 0.055so close (0.05 < p ≤ 0.1)

On multivariate analysis adjusting for relevant factors, low GNRI remained an independent predictor of both worse PFS (HR 2.84, 95% CI 1.34–6.02, p = 0.006) and OS (HR 3.09, 95% CI 1.40–6.82, p = 0.005), whereas IPI ≥ 3 independently predicted inferior PFS (HR 2.11, 95% CI 1.03–4.32, p = 0.042) but showed only borderline significance for OS (HR 2.09, 95% CI 0.99–4.41, p = 0.055).

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showed a trendp = 0.055so close (0.05 < p ≤ 0.1)

The IPI score ≥ 3 was an independent predictor of inferior PFS (HR 2.11, p = 0.042) and showed a trend toward worse OS (HR 2.64, p = 0.055) in multivariate analysis, reinforcing its established role in identifying high-risk patients, including those aged ≥ 80 years, as supported by prior studies [ 16 , 28 ].

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