Among individual GLP‐1 RA agents, the association was statistically significant for liraglutide (HR 1.17; 95% CI, 1.09 to 1.25) and semaglutide (HR 1.07; 95% CI, 1.01 to 1.13), but did not reach statistical significance for tirzepatide (HR 1.07; 95% CI, 0.96 to 1.12). 4 DISCUSSION In this large, new‐user, active‐comparator cohort study of adults with type 2 diabetes and overweight or obesity, we found that initiating a GLP‐1 receptor agonist was associated with a 9% higher relative rate of incident depression compared to initiating an SGLT2i.
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Risk of depression with GLP-1 receptor agonists use in overweight or obese adults with type 2 diabetes: A new-user, active-comparator cohort study.
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