Sustained reductions in valine and isoleucine mediate anti-cancer pharmacological effects of inhibiting amino acid transporter LAT1 in cancer cells.

2 below), both siRNAs selectively and significantly decreased Val, Ile, and Trp, accompanied by an increasing trend in Met and most non-substrate amino acids (Supplementary Fig.

also in 63,971 other papers

Individual and combined amino acid deprivation significantly enhanced or showed a trend to increase the eIF2α phosphorylation in MIA PaCa-2, HPAC, and SUIT-2 cells, indicating the activation of the GAAC pathway.

also in 53,322 other papers