Cortical versus hippocampal network dysfunction in a human brain assembloid model of epilepsy and intellectual disability.

In contrast, this phase relationship was disordered in both P1 and P2 Mut Hc+GE ( Figures 4C – 4E ), with significant or nearly significant reduced monophasicity ( Figure 4F ), despite no difference in theta power ( Figure 4G ) or consistent change in gamma power ( Figure S2A ) across all p.SCN8A lines.

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