The crossroads of inflammation and nutrition: predicting neoadjuvant immunochemotherapy efficacy in esophageal squamous cell carcinoma patients.

In the 900th Hospital cohort, the AUC difference between the SII-PNI score and SII or PNI did not reach statistical significance, which may be due to the small sample size and insufficient statistical power, resulting in effects that exist but do not reach statistical significance.

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Results demonstrated that, in most subgroups, patients with poorer SII-PNI scores (1-score group and 2-score group) showed an increasing trend in mortality risk for OS ( Figure 4 ) and disease progression risk for DFS ( Supplementary Figure 3 ) compared to 0-score group, with risk exhibiting a graded dependence on score severity (higher risk in 2-score group than in 1-score group). 4.

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