Identification and rescue of congenital hyperinsulinism-associated ABCC8 mutations that impair K<sub>ATP</sub> channel trafficking.

We found that the P133R and G228D mutants showed trends of higher mean current increase upon PIP 2 exposure than WT, but the differences did not reach statistical significance; while the Y124F mutant showed current fold increase by PIP 2 comparable to WT ( Fig. 7 ).

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